Once I started on tirzepatide, and then with retatrutide, the "urge" to swap over to my PC between meetings and load up a game is pretty much zeroed out.

Is this an "addiction" or a form of "abuse" similar to alcohol or other drugs? I would have said no some time ago, but now I'm not sure. I definitely feel like, looking back, I was more or less "addicted" to video games. I don't want to romanticize it as some sort of "escape", it just is what it was.

This was an unintended side effect (benefit?) of the drug for sure, in addition to acute weight loss of course.

Unlike many others, even after titrating down and coming off the GLP's, I have not felt the urge to binge food, video games, or anything else. I maintain a healthy, active lifestyle and have kept my weight exactly where I prefer it. My relationship with my body and my time has massively improved. I feel like I am at risk of sounding like a complete shill, obviously, but in my mind these drugs can be something that absolutely has the potential to turn life around for many, many people.

Almost 2 years now. I'm not religious about it and will occasionally drink the celebratory glass of bubbles or a beer (alcohol free if available) when it's hot outside.

Very interesting how it has worked.

It’d be interesting if these meds help with weight and addiction or just even overdoing it regularly.

I think this quote is... wrong? Or at least extremely misleading? Here, citation 72 refers to a paper by Henderson et al. That paper did (sorta) reduced laboratory alcohol self-administration, but did not find any reduction in the amount that people drank. https://dynomight.net/glp-1/

However, Ozempic will be generic early 2026 in Canada, and there's no way in hell I would pay 4-5x the difference (I'm guessing) for mounjaro as the benefit is relatively minor already given the half life difference (right now the price is almost the same).

I’m not diabetic, so my insurance doesn’t cover it, meaning I have to pay full price, which only went up after Eli Lilly switched from vials to pens in Canada. I genuinely hate Eli Lilly for : 1) their pricing, 2) for eliminating vials in favor of pens, and 3) for how they handled my situation. I reached out to their customer service honestly, admitting I wouldn’t qualify for a discount (even though I’d seen countless Reddit posts from people lying on the form and getting approved anyway and told them this). I reached out and requested in good faith and was flat-out denied, basically brushed off by their support team. This destroyed a lot of goodwill i had initially towards them because of better results and any future brand loyalty I might have had.

Does GPL-1 also dampen those? How much does it dampen just any fixed behavior?

Thank God, because my $60 strike call options just turned from a $55k loss to a $180k gain overnight. I shoulda read the CVRs BEFORE buying calls, but I was so blinded by the prospect of easy M&A arbitrage gains I couldn't risk missing out by taking 30 minutes to read the terms of the acquisition.

Glad I have the chance to quit while I'm ahead! Last time I ever fuck around with options trading!

One breakthrough and then a WHOLE BUNCH OF NEW STUFF happens all at once now that this new idea or new pathway is created.

mRNA vaccines break away and now they're testing them in everything. GLP-1 showing signs of use in obesity and now it's being tested for a whole gamut of other things. All very exciting!

99% of promising mice studies does not result in clinical practical application in humans. And theoretical associations and mechanisms of action should not be promoted without huge asterisk to contextualize how often such speculation are wrong.

If you complain about AI slop and don’t see how this is just as bad science slop, please go listen to Sabine Hossenfelder. This is just as bad, and create just as much useless noise as AI content does on the nett.