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Show HN: GeneGuessr – a daily biology web puzzle

85 points by brinedew

by jfarlow

1 subcomments

This is a challenge, even for someone who has professionally used the breadth of proteins. I really like the test. I'm actually kind of surprised at my own pulling on knowledge to make a guess - it's an orthogonal way to think about the question than is usually posed.
I wonder if there's a way to ease the difficulty by filling in 'correct' features of the guesses: if your guess is a 'transmembrane' then it reveals that as a property. On the other hand, I don't think the annotations are clean enough - and are often designed for 'at all' rather than 'primary' features. For one of the examples, once I noticed it was an adhesion protein, it would have been interesting to sift through classes or cell types as opposed to just continuing to shoot in the dark based on the structure alone.
I presume you're showing even the 'low confidence' portions of the predicted structure? Please do.
You could also show the primary amino acid sequence too - there's a weird familiarity with those given how often the structures themselves have historically not been so accessible. BLASTING each of the guesses would be another interesting thing to see.

by noduerme

2 subcomments

Huh. Is this kind of manifold something that a group of humans can now identify on sight and associate with a part of a DNA sequence? That's pretty spectacular. I have a friend who worked for years on AlphaFold, but wasn't aware that people had gotten to this level of confidence in visually identifying proteins.

by boldlybold

1 subcomments

Great work! I really like the interface here, I think you put a lot of taste into the way this all came together. It's quite hard (appropriately so!) I would love to see a experienced structural biologist go at this.

by pks016

0 subcomment

Cool game. Harder for me. I have background in most of the undergrad and some grad molecular biology. Still, the hints didn't help much. The most useful hints were on function of the gene and cellular components. Also, I have been out of touch with gene names from the last few years. I tried searching using a gene's function but didn't work as much. At the end I got 81% close but far from the answer.
You could start with popular gene names.

by miladyincontrol

0 subcomment

by oreilles

1 subcomments

Clicking the leftmost menu icon raise the following error:

    Geneguessr encountered a problem:
    runtime-error
    SyntaxError: redeclaration of const NAVIGATION_START

by RestartKernel

0 subcomment

This seems super well-done, albeit completely impossible for laymen. Great work, I'd love to see someone with the necessary knowledge play this.

by lovegrenoble

1 subcomments

by andrewrn

0 subcomment

by ithkuil

0 subcomment

by maximgeorge

0 subcomment