by dlcarrier
3 subcomments
- There was a guy on YouTube who genetically engineered himself to gain lactose tolerance. (https://www.youtube.com/watch?v=J3FcbFqSoQY)
It lasted for around a year and a half (https://www.youtube.com/watch?v=aoczYXJeMY4) before the effect mostly wore off. He took it orally, so it only affected his intestinal lining, and I presume it didn't effect enough stem cells to get a permanent effect, but it would still be usable as something taken annually, which is still far less often than any medication.
- Your genes seem to be out of date, there are several security updates pending. The download will be 3.2 Gb and will take about 3 seconds..... Because this is a security update you can not refuse it. If you are commanding a vehicle park it now or switch to autopilot. Commencing update in 10, 9, 8, ...
- Very dumb question, but how exactly does gene therapy work in vivo? Don't you have to modify every cell (or affected type of cell) with a new copy of the DNA? How does that actually.... happen?
- What enabled this treatment to be used now? Gene editing techniques have existed for a long time, but there were many reasons why they weren't being used in humans, like concerns about off-target edits and heritability. The article mentions something about gold nanoparticles, but this aspect was developed over the course of a few weeks, and in any case these aren't new either.
by polishdude20
0 subcomment
- Ho does one just summon a group of highly skilled researchers to help out a baby? Like, how did these researchers get paid?
- That's promising.
Where do I sign up?
I need my entire DNA code reprogrammed :)
by ChrisArchitect
0 subcomment
- Story from May;
Discussion then: https://news.ycombinator.com/item?id=43997636
- Direct link to downloadable paper:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12713542/
by gigatexal
2 subcomments
- What worries me is the attacks on universities and the breaking of public private research based on this comment from the article:
"In a race against time, scientists and doctors across the U.S. developed the first in vivo gene therapy, thanks to decades of medical research."
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12713542/
(without paywall)
- From the paper: "After regulatory approval had been obtained for the therapy, ..."
Are the documents relating to this FDA (?) approval application public? I'm curious about where the current boundaries lie and how the process works.
- "Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease"
https://www.nejm.org/doi/full/10.1056/NEJMoa2504747
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