It should be pointed out that the pituitary gland sits at the base of the brain and prolactinomas are not technically considered "brain tumors" because they're not in the tissue of the brain. So it's a mischaracterization to keep referring to this as a "brain tumor" and a bit of an odd one for someone trying to start a medical research effort.

Unfortunately, the reality is that sometimes life just doesn't deal you a good hand. I think it's sad this man is talking about children when prolactinomas are a leading cause of infertility and it sounds like, for a variety of reasons, this man's girlfriend has one that is very difficult to treat. While it's OK to always hope, it's also possible to cling to false hope so strongly that it prevents you from accepting and moving forward with the life you have instead of the life you envisioned.

Did she ask you to cure this tumor? Did she ask you to post about it?

This is a common story in disability and chronic illness communities -- a partner gets so fixated on the illness they forget the human afflicted with it. The ill partner goes to the grave wishing their partner would stop fighting and start just spending their remaining time filling their lives with joy.

It leads to especially dark places when they don't succeed.

I wish him all the best, but don't lose sight of the human suffering the illness and what they want.

Otherwise what's left? Hope your AI collaboration reveals novel untested compounds or interventions and somehow forgo all standard testing for safety and effectiveness and just produce and adminster them to her?

Obviously the goal would be to find some intervention that a) works b) has no serious lasting side effects. Hopefully the author and wife don't choose to forgo all other recommended treatments in the meantime hoping the AI driven clinical trials can be speedrun or that AI is so smart clinical trials are uneccesary.

About the kids thing: Genetic causes for these are super hard to isolate but if, perchance, science sees fit to give us the information then you do have embryo selection available to make this choice safely.

Rooting for the two of you. And just wanted to thank you for the story. The sum of anecdotes often is the source for good hypotheses for science. I think you’re doing a good thing sharing what you’re doing.

I would strongly suggest seeing a therapist. I’ve experienced traumatising moments in life, and therapy has been a great help.

Hopefully with a better end.

LLMs might be useful at generating text, but they cannot research, fund, develop, manufacture, educate, distribute, treat.

Like others have said, focus on speaking with your partner and deciding your plans together.

if you think life is only rational its more likely lack of experience than knowing it better. Most of life, is infact not rational.

I'd want to tell him to save himself, but i do hope he saves her,.because regardless of anyone's words, he wont give up, maybe destroy himself too, and thats ok.

I am truly sorry how unfair life can sometimes be. I wish such things not on my worst enemies. I hope in some aspect of life Love will persist, prevail or return into your life OP.

We've been using "AI" in science far longer than you realise. We happily take on new tech at breath taking speed.

Don't waste your time, please just focus on her and not the disease.

some people do manage to cure their own disease sometimes.

Then, one day, the tide comes in. You learn what old men know. What women know. What every victim of circumstance knows. Sometimes the world just happens to you.