Historically, you'd get your polyphenols from your garden or wild gathering. But we know that industrial crops (even organic grown) have extremely low polyphenol content compared to their wild counterparts. So coffee remains as one of the few strong sources you can buy in a grocery store.

Hypothesis: Polyphenols from other sources would be just as protective as coffee.

So I am hoping there are confounding factors in all these studies, such that it's not coffee per se that helps with dementia but rather something along the lines of "the type of person who desires coffee is less likely to develop dementia".

https://www.massgeneralbrigham.org/en/about/newsroom/press-r...

“We also compared people with different genetic predispositions to developing dementia and saw the same results—meaning coffee or caffeine is likely equally beneficial for people with high and low genetic risk of developing dementia,” said lead author Yu Zhang

That seems like it indicates there is some real, independent signal here. Off to make some coffee!

1. Why did they source men and women from separate studies?

2. How can they tell the study's results aren't equivalent to "people with dementia are bad at logging their caffeine intake reliably"?

Ever since I stopped drinking that mini-panic-attack potion, my heart hasn’t skipped a beat, my sleep has been great and I don’t feel tired all the time.

Hopefully one day people wake up (haha) and dump it the way we’ve dumped cigarettes.