Technically not. It can run it. Was slow? Yes, but my Am386DX40 keep working fine from 1991 to 1996. Running DR-DOS 6, MS-DOS 6.11, Windows 3.1 and finally Windows 95. And, of course, I could play DooM 2 on it. At some point, I got a math copro. Finally, my father upgraded the machine with an AMD 486DX5 133MHz.
Edit: It might be cool to make a higher-spec TMS9900 home brew system.