by chewbacha
2 subcomments
- This is cool but I’m sorry, that’s not a vaccine - it’s a prophylactic.
A vaccine or inoculation is named because it creates a sustained adaptation to a targeted antigen. Something that boosts immune response is not an acquired adaptation! This would need to be re-upped every month or so.
Good for travel and brief encounters. Not an actual immunization.
Not too mention boosting cell growth factors can have unintended side effects like cancer! There are immune system cancers and I would be concerned about risks there.
by cameldrv
12 subcomments
- This seems too good to be true. Respiratory infections kill and debilitate a lot of people. If cranking up the innate immune system all the time reduced illness with no downsides, you'd think evolution would have done it already, but it didn't, which makes me think there's probably a downside, and the fact that the innate immune system is only cranked up when a pathogen is detected is probably because the downside is worth it in the presence of a pathogen but not otherwise.
by torgoguys
8 subcomments
- I don't know much about this, but wouldn't the description of this imply you're stimulating the body to be in an a long-term situation that would be commonly viewed as unpleasant (inflamed, maybe nasal drainage, that type of thing) with the positive tradeoff that you get fewer actual infections?
- What intrigued me the most is why their vaccine reduces allergic reactions too. If the allergic reaction is an immune response, why does administering the vaccine which increases immune response result in a decreased allergic reaction? I'd expect the opposite.
- IN MICE should be added to this title
by Horatius77
6 subcomments
- Appears that it is trying to stimulate broad immunity .. instead of any one specific virus/disease. Artificial and overstimulation of our immune systems long-term can't be healthy. Definitely a tradeoff here.
- Hopefully this wouldn't trigger autoimmune conditions.
- 3M-052 again? Oh, for fuck's sake. We've been down this road for 15 years now. Every funder who learns about the interferon cascade gets a boner. And then they go to animal trials and meet disappointment. If these guys can get to an IND, good on them, but 3M is really licensing the shit out of this one.
Meanwhile, if you've got spare millions laying around, have a look at ENA Respiratory. They've already done a Phase 1 in Australia (entirely admissable for the FDA). Turns out hypoxia creates and anxiety and old people have most of the world's wealth, so COPD is a lucrative market.
Another super interesting one is Lumen Biosciences - can't make oil from algae at a viable price point, but for sure they can hit pharma price points, even food supplement price points.
by JumpCrisscross
0 subcomment
- Study: https://www.science.org/doi/10.1126/science.aea1260
https://sci-net.xyz/10.1126/science.aea1260
- In mice?
- What a time to be a Mice!
by ChrisArchitect
0 subcomment
- 3 weeks old story;
Some discussion: https://news.ycombinator.com/item?id=47080267
- Didn‘t we something similar with antibiotics?
At first they helped against a broad spectrum of bacteria but then the bacteria evolved.
Damn you Darwin and your evolution.
by deepriverfish
1 subcomments
- as someone with chronic nasal allergies, would this work for me?
by dune-aspen
0 subcomment
- [flagged]
by SilentM68
1 subcomments
- [flagged]
- [flagged]
by jasonvorhe
0 subcomment
- [flagged]
by dennis_jeeves2
2 subcomments
- [flagged]
- In mice
- Good news! Also, AI thumbnail defies all physical laws.
by analog8374
0 subcomment
- I want my body to be a product sold to me by a corporation.
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