- I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range.
I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells.
In other words, don’t expect to replicate these results with normal recreational use.
- Too bad we've had like a half-dozen putative Alzheimer's drugs that clear amyloid beta that turn out to do nothing to slow or prevent Alzheimer's.
Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?
- This appears to be dated 2016. Did the preliminary results amount to anything?
- Yes but.. Amyloid-beta may be part of the innate immune system
https://news.harvard.edu/gazette/story/2010/03/alzheimers-as...
by laughing_man
2 subcomments
- Do we still think clearing beta amyloid plaques will halt the progress of Alzheimer's? My impression is we're treating marker for the disease and not the cause.
by rusakov-field
3 subcomments
- Man, too bad weed gives me bad panic attacks. Alzheimers is the scariest disease I know so maybe if the studies pan out in time and it becomes a standard preventative, I might consider trying again.
But somehow I doubt it will be found to be that effective.
- Pro: Salk Institute
Con: Preliminary Research, In Vitro
- For those interested in this and preventative measures, there's been reports about lithium helping prevent Alzheimer's: https://hms.harvard.edu/news/could-lithium-explain-treat-alz...
Standard disclaimers apply.
by ProjectArcturis
0 subcomment
- There are easily hundreds of compounds that can reduce beta-amyloid in vitro. This is a decade-old nothingburger.
- There was another recent study showing that THC was creating false short term memories - like "I swear I told you that" - but never did.
Cannabis really needs a lot more study.
- I have more trust on 40 hz ultrasound therapies.
- There was another recent study showing that THC was creating false short term memories - like "I swear I told you that" - but never did.
by colordrops
1 subcomments
- Anecdotally, when I'm feeling scattered and foggy, when I take a big hit off of my vape pen, I go through a period of noticing how shaky my appendages are, and go through what feels like a physical process of the sensation of my mind "unwrinkling" or unfurling. I often wondered if something was being cleaned out in my brain because I usually feel a lot more calm and still afterward, thoughts more collected.
- "reefer madness" has put legitimate research of that plant back immeasurably
by meetpaleltech
0 subcomment
- ...which is offset by typical dementia-like effects, other cognitive impairments in chronic weedos.
- Get stupid now to avoid cognitive decline later? Not sure I like that tradeoff...
by mistermaster1
0 subcomment
- [dead]
- [dead]
- And yet, has anyone ever claimed regular marijuana use improved their memory?
- [flagged]
- Remove them and replace them with...Doritos?
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