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Training mRNA Language Models Across 25 Species for $165

145 points by maziyar

by seamossfet

1 subcomments

The problem with models like this is they're built on very little actual training data we can trace back to verifiable protein data. The protein data back, and other sources of training data for stuff like this, has a lot of broken structures in them and "creative liberties" taken to infer a structure from instrument data. It's a very complex process that leaves a lot for interpretation.
On top of that, we don't have a clear understanding on how certain positions (conformations) of a structure affect underlying biological mechanisms.
Yes, these models can predict surprisingly accurate structures and sequences. Do we know if these outputs are biologically useful? Not quite.
This technology is amazing, don't get me wrong, but to the average person they might see this and wonder why we can't go full futurism and solve every pathology with models like these.
We've come a long way, but there's still a very very long way to go.

by maziyar

2 subcomments

by nradclif

0 subcomment

"Complete results, architectural decisions, and runnable code below."
This is a weird post, there doesn't seem to be any "below" here. Another comment linked the article: https://huggingface.co/blog/OpenMed/training-mrna-models-25-...

by jazzpush2

0 subcomment

A Codon-based model is cool. I know NVIDIA is building quite a large one.
At GTC they showed an SAE they built on a smaller version of it, allowing you to see what their model learned: https://research.nvidia.com/labs/dbr/blog/sae/

by rubicon33

1 subcomments

Can someone explain what one might use this model for? As a developer with a casual interest in biology it would be fun to play with but honestly not sure what I would do

by dhruv3006

0 subcomment

by khalic

1 subcomments

by colingauvin

0 subcomment

HN's blindspots never cease to amaze me.
I am a structural biologist working in pharmaceutical design and this type of thing could be wildly useful (if it works).

0 subcomment

by yieldcrv

0 subcomment

Distributing the load on this will probably be infinitely more useful than “folding at home”

by simianwords

1 subcomments

What makes these Domain specific models work when we don’t have good domain models for health care, chemistry, economics and so on

by HocusLocus

0 subcomment

by skyskys

0 subcomment