This is interesting in that it seems to be making the grind more efficient. I think the true breakthrough will likely be proper scale quantum computing to make the first principles design feasible

Its curious that they picked this example. The challenge with HKMG was not the material itself, but how to integrate into into the transistor stack.

There were two completely different approaches: Gate first and replacement gate. Gate first is what the industry was already using for silicon oxide so everybody tried to go with as little change as possible. Only intel decided for replacement gate, which worked much better and reaped some other benefits on the way.

This was a watershed moment in the industry and ultimately led to some of the players dropping out of the cmos race.

But is this really a "scale-up" problem? It required development of novel manufacturing processes (atomic layer deposition), but was still mainly a process integration and device engineering topic.

The part of the thesis I have to agree with is that there is a data problem. The development above relies on executing lots of time consuming and tedious split experiments that often cannot be parallelized. The outcome of this relies heavily on the experience and diligence of the experimenters.

It's probably well suited for an "autoresearch" approach, bridging to the phyiscal world and dealing with the timescale is the challenge.

I think the distinction between discovering a material and processing / scaling it up is a bit artificial. A lot of people think of a new material as just the crystal structure or something, but really all the defects and complex multiscale structure is just as much part of what defines a material, and controlling all that is why materials development is hard, and why you need so many different complementary measurements to understand what’s going on

I was a bit underwhelmed by this writeup because it’s a bit generic. I didn’t really see any specific new ideas on how to accelerate this process, or to differentiate from the main stream of materials discovery research which has been pretty dominantly AI forward for at least five years now

EDIT: I checked out some of their case studies and they’re pretty interesting and exploring some new materials characterizations territory. They’d be more impactful if they were more than just text IMO but much more concrete and less generic than the linked post

Do they? There’s plenty of stuff in our labs, most of them are completely useless, some that were bought to be useless become fashionable again, and we get new and exciting ones every day. There are a lot of issues in going from concept to useable material, and "scaling up" is only one of them.

> FRONTIER INTELLIGENCE WILL BRING THEM TO THE WORLD.

It will probably help, but I doubt it will do it by itself.

> Put simply, materials innovation has a scale-up problem, not a discovery problem.

I just don’t think that’s true. It’s also a scale-up problem, but discovery itself is not solved.

The problem spaces keep getting larger (composites! nanostructures! High-entropy!). High-throughput thermodynamic and electronic structure calculations, automated characterisation and testing, and things like that are being developed because we just don’t know what materials could exist and what could be their properties. The problem is that while there is room for AI there, particularly in automation, even cutting edge models are very dodgy to extrapolate materials properties outside their training sets, which are utterly negligible compared to the size of the search space.

> The bottleneck has never been a shortage of promising candidate materials. It is the decades of trial and error it takes to manufacture even one of them reliably.

It’s worse than that. The first sentence is true (ideas are cheap), but the main bottleneck is to try to figure out the properties of the damn thing and whether some of them are deal breakers or not. The vast majority of materials we come up with never see any application, not because we don’t have processes at the right scale, but because they just have terrible properties.

Building is cheap. Distribution, differentiation and discovering unmet demand are becoming the expensive parts.