1. From my own experience, most people who use a ZIL for faster sync writes are wasting space. You only need five seconds of peak throughput (for a 10Gb connection that's ~5 GB). Create a pair of 25 GB partitions for the ZIL rather than dedicating entire devices.
2. With the remaining space set up a mirrored Special VDEV with heavy use of small blocks. 32k block sizes will still give some room for compression which, other than saving space, can increase throughput and reduce IO/ps.
3. Pause scrubs (`zpool scrub -p`) when the workload is either expected to be heavy or is actually heavy based on moving averages and resume when its safe. Even my 24 TB NAS takes 24+ hours with no other activity.
Of course, this is also not a fast command on a slow array; my half full 2x 24TB mirror is estimating ~ 12 hours to run this; the last scrub took just over 24 hours to run. (After I posted, the remaining time dropped to 10 minutes... not as slow as it seemed, but still slow, and using a lot of I/O ... left for lunch and 50 minutes later it's almost done; estimation is hard)
It's so hard to wade through run on sentences like "The knobs are not the problem. The pool was designed without room for this workload."
I stocked up on a few shuckable externals before the start of the second Grump catastrophe. $280/24TB (Exos inside). I'm finally getting around to setting up a pool, thinking 4+1 is kind of poor redundancy and wondering about adding another disk. The things are up to over $1,000 each, in the husk or not. Fucking hell. It makes me want to drastically scale back the size of my new pool in case a drive does die so I don't end up needing to buy a replacement any time soon.