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Building a Quake PC 27 points by roskelld | 13 Comments

Bringing the Predators to Life in MAME 74 points by msephton | 16 Comments

Use of Bayesian methodology in clinical trials of drug and biological products [pdf] 69 points by brendanashworth | 21 Comments

I set all 376 Vim options and I'm still a fool 31 points by todsacerdoti | 5 Comments

Show HN: Gambit, an open-source agent harness for building reliable AI agents 90 points by randall | 22 Comments

How to wrangle non-deterministic AI outputs into conventional software? (2025) 30 points by druther | 21 Comments

Independent Guest Virtual Machine (IGVM) File Format 27 points by ingve | 9 Comments

First impressions of Claude Cowork 234 points by stosssik | 140 Comments

Iran's state broadcaster IRIB was hacked to air a message from Reza Pahlavi 15 points by seymon | 14 Comments

pf: Make af-to less magical 52 points by defrost | 15 Comments

Ford F-150 Lightning outsold the Cybertruck and was then canceled for poor sales 677 points by MBCook | 959 Comments

Why senior engineers let bad projects fail 266 points by SupremumLimit | 162 Comments

We Gave Our Browser Agent a 3MB Data Warehouse 36 points by shardullavekar | 5 Comments

Ask HN: Claude Opus performance affected by time of day? 38 points by scaredreally | 36 Comments

System Programming in Linux: A Hands-On Introduction "Demo" Programs 127 points by teleforce | 7 Comments

Musk Seeks Up to $134B Damages from OpenAI, Microsoft 29 points by SanjayMehta | 11 Comments

Artisanal Code 24 points by sunnyam | 7 Comments

Raspberry Pi's New AI Hat Adds 8GB of RAM for Local LLMs 253 points by ingve | 208 Comments

I hate GitHub Actions with passion 489 points by xlii | 340 Comments

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